This paper aims to design an inventory model for a retail enterprise with a profit maximization objective using the opportunity for a price discount facility given by a supplier.In the profit maximization objective, the demand should be increased.The demand can be boosted by lowering the selling price.However, lowering the selling price may not alw
Activating mutations in KIT/PDGFRA receptor tyrosine kinases drive gastrointestinal stromal tumors (GIST).KIT/PDGFRA inhibitors, such as imatinib do not evoke an effective cytocidal response, leaving room for quiescence and development of multiple secondary resistance mutations.As the majority of the secondary resistance clones activate PI3K and MA
The Indigenous tribe called the Wiwa lives retracted in the Sierra Nevada de Santa Marta, Colombia.Little is known about their health status and whether the health care system in place covers their needs.In 2017 and 2018, a permanent physician was in charge for the Wiwa.Diseases and complaints were registered, ranked, and classified with the ICD-10
Introduction: Anterior approach provides excellent visualization and access to the anterior thoracic spine.It may be used alone, in combination with a posterior midline approach or in a staged or sequential fashion.Aims: To analyse our institutional experience in transthoracic approaches and to determine the safety and Stove Burner benefit of this
Hydropower is the largest renewable energy source in the world.However, in the Columbia and Snake River basins, several species of Pacific salmon and steelhead have been listed for protection under the Endangered Species Act due to significant declines of fish population.Dam operators and design engineers are thus faced with the task of making hydr